In your theme directory
In your /app/design/frontend/yourthemepackage/default/template/checkout/cart.phtml file OR /app/design/frontend/default/yourtheme/template/checkout/cart.phtml file
<form action="<?php echo $this->getUrl('checkout/cart/updatePost') ?>" method="post">
<?php echo $this->getBlockHtml('formkey'); ?> <!-- this line must be there -->