第一种方法：


//设置两种字体大小
        Spannable WordtoSpan = new SpannableString(codeMemoTV.getText().toString());
        WordtoSpan.setSpan(new AbsoluteSizeSpan((int) DimensionUtil.convertDpToPixel(18, this)), 0, 8, Spannable.SPAN_EXCLUSIVE_EXCLUSIVE);
        codeMemoTV.setText(WordtoSpan);

        //设置两种字体颜色和大小
        Spannable WordtoSpan1 = new SpannableString("好友成交额6255.50元");
        WordtoSpan1.setSpan(new AbsoluteSizeSpan((int) DimensionUtil.convertDpToPixel(18, this)), 5, 8, Spannable.SPAN_EXCLUSIVE_EXCLUSIVE);
        WordtoSpan1.setSpan(new ForegroundColorSpan(getResources().getColor(R.color.black)), 5, 8, Spannable.SPAN_EXCLUSIVE_EXCLUSIVE);
        codeMemoTV.setText(WordtoSpan1);



或者： 


msgTV.setText(Html.fromHtml(String.format("%s出价 <font color=\"#f06c55\">%.0f</font>元", item.getIsPerPrice() , item.getBidPrice())));



效果图：

一个文本框2种字体大小、颜色_字体