nmcli connection reload +网卡名 

nmcli connection reload eth0

重载所有ifcfg或route到connection(不会立即生效) 

nmcli connection reload  ifcfg-eth0

重载指定ifcfg或route到connection(不会立即生效)​ 

nmcli connection load /etc/sysconfig/network-scripts/ifcfg-eth0
nmcli connection load /etc/sysconfig/network-scripts/route-eth0

立即生效connection，有3种方法

nmcli connection up eth0
nmcli device reapply eth0
nmcli device connect eth0

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Linux,oracle