32down voteaccepted

Yes, a Chrome Extension "content script" can run in all iframes (that are initially in the HTML when the page is loaded). In order to have the content script run in all frames you need to configure it to do so in the Chrome Extension manifest.json using the ​​all_frames​​ property:

​http://code.google.com/chrome/extensions/content_scripts.html​

{   "name": "My extension",   ...   "content_scripts": [     {       "matches": ["http://www.google.com/*"],       "css": ["mystyles.css"],       "js": ["jquery.js", "myscript.js"],       "all_frames": true     }   ],   ... } 

No, the content scripts will NOT execute in the iframes loaded dynamically via JavaScript in the page.