发表在 Nucleic Acids Research, January 2018, , https://doi.org/10.1093/nar/gkx1132
已有的同类数据库不少，比如： KEGG (http://www.ensembl.org/Homo_sapiens/Info/Annotation),
事实上，最新版是 ： Version 64 released on March 26, 2018
2102 pathways (e.g. Interleukin-15 signaling; ) grouped into 26 superpathways
1334 mutant variants and their post-translationally modified forms derived from 285 gene products, used to annotate 906 disease-specific reactions, tagged with 294 Disease Ontology terms
1768 small molecules as substrates, catalysts, and regulators in 11 302 reactions annotated on the basis of data from 27 526 literature references
开放下载
The Reactome graph database is freely available at: https://reactome.org/dev/graph-database. The API for the ContentService is available at https://reactome.org/ContentService with documentation and tutorials available at: https://reactome.org/dev/content-service. The Java source code is freely available at: https://github.com/reactome in the graph-core, graph-importer and content-service repositories.
网络学习资源
Reactome online resources
an introductory video for users
includes graph-core, graph-importer, content-service and analysis-tools repositories
reusable stand-alone JavaScript EHLD viewer
community contributions to the library
简单探索
10788 Arabidopsis thaliana
16811 Bos taurus
9848 Caenorhabditis elegans
14850 Canis familiaris
19381 Danio rerio
4353 Dictyostelium discoideum
15820 Drosophila melanogaster
13977 Gallus gallus
40404 Homo sapiens
27359 Mus musculus
40 Mycobacterium tuberculosis
9054 Oryza sativa
1774 Plasmodium falciparum
22109 Rattus norvegicus
5116 Saccharomyces cerevisiae
3896 Schizosaccharomyces pombe
12573 Sus scrofa
3459 Taeniopygia guttata
7864 Xenopus tropicalis
在人类里面记录了 1772 个通路。
有一些通路基因比较多，也有一些通路甚至只有一个基因。
479 Neutrophil degranulation
392 Olfactory Signaling Pathway
343 Generic Transcription Pathway
310 Antigen processing: Ubiquitination & Proteasome degradation
266 G alpha (i) signalling events
235 Neddylation
220 Ub-specific processing proteases
207 SRP-dependent cotranslational protein targeting to membrane
206 HATs acetylate histones
190 Separation of Sister Chromatids
1 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P
1 Tandem pore domain halothane-inhibited K+ channel (THIK)
1 TLR3 deficiency - HSE
1 Toll Like Receptor 10 (TLR10) Cascade
1 Transport of connexons to the plasma membrane
1 TWIK-related spinal cord K+ channel (TRESK)
1 Variant SLC6A14 may confer susceptibility towards obesity
1 Vitamin E
1 WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
1 ZBP1(DAI) mediated induction of type I IFNs